This Is Us creator Dan Fogelman is bringing his special brand of life-affirming (and tear-jerking) family stories to Amazon Studios with his new movie, Life Itself. The film, set in New York and Spain, centers on a couple (Oscar Issac and Olivia Wilde) as they embark on their lives together. Knowing Fogelman, there’s bound to be a twist (or several) and tears a plenty.

According to the studio’s website, the movie’s leads are the center of a “multigenerational love story spanning both decades and continents, from the streets of New York to the Spanish countryside, and are all connected by a single event.”

The trailer starts with Issac and Wilde sitting on a stoop in New York. She asks if he’s ever going to ask her out, to which he says he’s waiting for the right moment, because, “when I ask you out, there’s not going to be any turning back for me. I’m not gonna date anybody else for the rest of my life. I’m not gonna love anybody else for the rest of my life. I’m waiting for the right moment because when I ask you out, it’s gonna be the most important moment of my life.”

While we don’t know what the single connecting event is, the trailer also features a disheveled Issac with the legendary Annette Bening, who asks him to tell her about a day he describes as “a completely random moment that … would shape my entire life.” Interspersed between those two conversations are flashes of scenes with his parents, a couple in Spain, a little girl, and other moments from the central romance.

“I love you, but I may not be equipped to be loved this much,” Wilde says at one point.

Life Itself also stars Oscar Cooke, Laia Costa, Sergio Peris-Mencheta, Mandy Patinkin, and Antonio Banderas. It’s set to be released on September 21 — just four days before season 3 of This Is Us is slated to begin. 

Will you check out Life Itself? Let us know @BritandCo!

(photos via Jose Haro/Amazon Studios + Amazon Studios)