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The OG medical drama is back. Grey's Anatomy returns for season 22 this October and we're in for even more crazy stories, surgeries, and memorable moments. And it looks like we could be saying goodbye to at least one character if the new trailer is any indication. Mom, I'm scared!! Keep reading for all the info you need to know before the new episodes drop.
Here's everything you need to know about Grey's Anatomy season 22, coming to ABC on October 9, 2025.
Is there a season 22 of Grey's Anatomy coming?
Yes, Grey's Anatomy season 22 is coming this fall — and the new teaser promises "everything is about to change" as it appears multiple characters are crying over a missing Link after he rushes into the burning hospital to find Miranda. Is he okay?! Is Miranda okay?! Hopefully we get answers sooner rather than later.
Where can I watch season 22 of Grey's Anatomy?
Disney/Anne Marie Fox
Grey's Anatomy season 22 is coming to ABC on October 9, 2025. The show will also be available to watch on Hulu.
Will Ellen Pompeo be in season 22?
Disney/Anne Marie Fox
Yes, Ellen Pompeo will return as Meredith Grey!
Who else is in the Grey's Anatomy season 22 cast?
Disney/Anne Marie Fox
The Grey's Anatomy season 22 cast includes:
- Ellen Pompeo as Dr. Meredith Grey
- Chandra Wilson as Dr. Miranda Bailey
- James Pickens Jr. as Dr. Richard Webber
- Kevin McKidd as Dr. Owen Hunt
- Caterina Scorsone as Dr. Amelia Shepherd
- Camilla Luddington as Dr. Jo Wilson
- Jason George as Dr. Ben Warren
- Kim Raver as Dr. Teddy Altman
- Chris Carmack as Dr. Atticus Lincoln
- Anthony Hill as Dr. Winston Ndugu
- Alexis Floyd as Dr. Simone Griffith
- Harry Shum Jr. as Dr. Benson Kwan
- Adelaide Kane as Dr. Jules Millin
- Niko Terho as Dr. Lucas Adams
How many episodes are in Grey's Anatomy season 22?
Disney/Anne Marie Fox
Grey's Anatomy season 22 will probably have around 20 episodes. Here's the schedule for the first few!
- Season 22, Episode 1 "Only the Strong Survive" premieres on ABC October 9, 2025
- Season 22, Episode 2 "We Built This City" premieres on ABC October 16, 2025
- Season 22, Episode 3 "Between Two Lungs" premieres on ABC October 23, 2025
- Season 22, Episode 4 premieres on ABC October 30, 2025
- Season 22, Episode 5 premieres on ABC November 6, 2025
- Season 22, Episode 6 premieres on ABC November 13, 2025
- Season 22, Episode 7 premieres on ABC November 20, 2025
Is Patrick Dempsey coming back to Grey's Anatomy Season 22?
Richard Cartwright/ABC/Disney
There's no official confirmation that Patrick Dempsey's McDreamy could make a special appearance on Grey's Anatomy season 22, but only time will tell whether we'll see him again.
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