George Clooney鈥檚 famous friends gathered on Thursday, June 7, to honor the actor at the American Film Institute鈥檚 Life Achievement Award ceremony. And while his wife, Amal Clooney, gave a heartfelt speech in tribute to her husband, most of the other presenters, including Jennifer Aniston and Courteney Cox, decided to take a different approach and have a little fun at his expense.

Aniston began by mentioning E.R., which Clooney starred in from 1994 to 2000, around the height of Friends鈥 fame. 鈥淭he success of [E.R.] can be explained in two words,鈥 she said, according to Entertainment Weekly. When Cox followed with, 鈥淕eorge Clooney,鈥 Aniston jokingly yelled, 鈥淟ead-in,鈥 referring to the fact that E.R. followed Friends on Thursday nights.

鈥淪he鈥檚 right,鈥 Cox quipped. 鈥淟et鈥檚 just admit it right here and now. There were millions of people watching Friends that happened to stay there, too lazy to turn the channel. Without us, you鈥檙e Chicago Hope, buddy.鈥

鈥淟ucky for you, George, we remained on the air on Thursday nights, pretty much paving the way for I鈥檇 say every success that you鈥檝e had since then,鈥 Aniston joked.

The duo then launched into a bit based on the Friends theme song. 鈥淚 mean this, in all seriousness, from the bottom of the both of our hearts, I鈥檓 going to be there for you,鈥 Aniston said, before Cox piped in, 鈥淲hen the rain starts to pour.鈥 Aniston then reiterated her previous sentiment, telling Clooney, 鈥淚鈥檓 going to be there for you, buddy,鈥 which paved the way for Cox鈥檚 鈥淟ike I鈥檝e been there before.鈥

Clooney made a guest appearance on Friends in the show鈥檚 first season, playing a sitcom version of his E.R. character alongside costar Noah Wyle. In 鈥淭he One With Two Parts: Part 2,鈥 Rachel sprains her ankle and pretends to be Monica so she can use her friend鈥檚 insurance at the hospital. When the women end up on a double date with the two cute doctors (Clooney and Wyle) who treated Rachel, things get messy. It might be worth a rewatch before the AFI Life Achievement Award: A Tribute to George Clooney airs Thursday, June 21, at 10pm ET on TNT.

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(photos via Kevin Winter/Getty Images for Turner + Frazer Harrison/Getty Images for Turner)